Ugrás a tartalomhoz

The Theory and Practice of Pharmaceutical Technology

Dr. Attila Dévay (2013)

University of Pécs Institute of Pharmaceutical Technology and Biopharmacy

The Theory and Practice of Pharmaceutical Technology

The Theory and Practice of Pharmaceutical Technology

Dr.. Attila Dévay

UP Institute of Pharmaceutical Technology and Biopharmacy

Dr.. Pál Szilárd

other developer 

Dr.. Pernecker Tivadar

other developer 

Dr.. Diós Péter

other developer 

Szilvia Czulák

technicaleditor 

Zsolt Bencze

technicaleditor 

Copyright 2013, Dévay Attila

2013


Table of Contents

Preface
1. Concept and short history of pharmaceutical technology until present
2. Substances for pharmaceutical use
Substances of mineral origin
Herb-derived substances
Volatile oils
Other herb-derived substances
Substances of animal-derived substances
Synthetic and other substances
Medicines produced with biotechnology
Nanomaterials
Active agents
Excipients
Vehicles
Basis
3. Operations and processes in pharmaceutical technology
4. Biopharmaceutical fundamentals of pharmaceutical technology
5. Design and optimization in pharmaceutical technology
6. Measurement
Weight measurement
Volume measurement
7. Heat transfer
8. Heat reduction
9. Evaporation and distillation
10. Mixing
Theory of mixing
Mixing of liquids
Mixing of semisolid materials
Mixing of solid materials
11. Dissolution
Solubility
Increase of solubility
Dissolution speed
12. Dispersing
Suspensions
Emulsions
13. Technology of semi-solid dosage forms
Preparation of ointments and creams
Preparation of suppositories
Preparation of vaginal suppositories
Preparation of sticks
Solid dispersions
Pelletizing
Extrusion
14. Extraction
15. Extrusion
16. Crystallization
17. Filtration
Macrofiltration
Gas filtration
Membrane filtration
18. Sedimentation
19. Drying
20. Particle size reduction
21. Sieving
22. Fluidization
Advantages of fluid bed technology
Disadvantages of fluid bed technology
Entraining of solid
23. Granulation
Theory of forming bindings
Effect of adhesion and cohesion forces in immobile liquid film
Effect of interfacial force in mobile liquid film
Creation of solid bridges
Significance of attraction force between solid particles
Mechanical interconnection
Mechanism of granule formation
Nucleation (creation of core)
Transformation
Increase of particle size and conglobation
Production of granules
Dry granulation
Melting granulation (preparation of sinter granules)
Wet granulation
24. Tabletting
Tablet presses
Eccentric tablet presses
Rotary tablet presses
Tabletting
Tabletting by direct compression
Tabletting based on dry granulation
Tabletting based on wet granulation
Special tabletting technologies
Advantages of application of tablets
Disadvantages of application of tablets
Possible applications of tabletting excipients
Enhancement of lubrication after compression
Biopharmaceutical and pharmaceutical technological viewpoints of tablets disintegration
Avoiding adhesion and picking during compression
Avoiding capping and layering after tabletting
Decrease of weight fluctuations of tablets
25. Capsules
Wafer capsules (cachets)
Soft gelatin capsules
Hard gelatin capsules
Capsules
Officinal capsules
Medium scale capsules
Industrial capsules
26. Coating
Dragée-making
Spray coating
Film coating
Excipients of film coating
Fluidized bed coating
Film coating flaws
Dry coating
Packaging
27. Multiparticulate dosage forms
Multiparticulate micro-pharmaceutical preparations
Minitablets
Micropellets
Microencapsulation
Multiparticulate pharmaceutical nano-preparations
28. Aseptic and parenteral pharmaceutical products
Sterilization methods
Dry heat sterilization
Moist heat sterilization
Radiation sterilization
Filtration sterilization
Chemical sterilization
Gas sterilization
Liquid antimicrobial chemicals
Gas plasm sterilization
Controlling sterilization efficiency
Sterile pharmaceutical products